• Western blot analysis using Crk II monoclonal antibody against LNCAP, A431, MCF7, HL1080 cell lysate.

Anti-CRK antibody (STJ98480)

SKU:
STJ98480

Current Stock:
Host: Mouse
Applications: WB
Reactivity: Human/Mouse/Dog/Rabbit
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Adapter molecule crk is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Conjugation: Unconjugated
Formulation: Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CRK
Gene ID: 1398
Uniprot ID: CRK_HUMAN
Specificity: Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.
Immunogen: Purified recombinant human Crk II protein fragments expressed in E.coli.
Function Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Protein Name Adapter Molecule Crk
Proto-Oncogene C-Crk
P38
Database Links Reactome: R-HSA-170984
Reactome: R-HSA-186763
Reactome: R-HSA-2029482
Reactome: R-HSA-372708
Reactome: R-HSA-4420097
Reactome: R-HSA-8849471
Reactome: R-HSA-8875555
Reactome: R-HSA-8875656
Reactome: R-HSA-912631
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cell Membrane
Translocated To The Plasma Membrane Upon Cell Adhesion
Alternative Antibody Names Anti-Adapter Molecule Crk antibody
Anti-Proto-Oncogene C-Crk antibody
Anti-P38 antibody
Anti-CRK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance