Post Translational Modifications | A N-glycosylation site within the signal peptide impedes its proper cleavage and function. |
Function | G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
Protein Name | Corticotropin-Releasing Factor Receptor 2Crf-R-2Crf-R2Crfr-2Corticotropin-Releasing Hormone Receptor 2Crh-R-2Crh-R2 |
Database Links | Reactome: R-HSA-373080Reactome: R-HSA-418555Reactome: R-HSA-422085 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Corticotropin-Releasing Factor Receptor 2 antibodyAnti-Crf-R-2 antibodyAnti-Crf-R2 antibodyAnti-Crfr-2 antibodyAnti-Corticotropin-Releasing Hormone Receptor 2 antibodyAnti-Crh-R-2 antibodyAnti-Crh-R2 antibodyAnti-CRHR2 antibodyAnti-CRF2R antibodyAnti-CRH2R antibody |
Information sourced from Uniprot.org