Whole cell lysates were separated by 12% SDS-PAGE, and the membrane was blotted with anti-CRHR2 (PTR1319) antibody. The HRP-conjugated Goat anti- mouse IgG (H + L) antibody was used to detect the antibody. Lane 1: Neuro-2aPredicted band size: 47kDaObserved band size: 47kDa

Anti-CRHR2 antibody (50-150) [PTR1205] (STJA0006274)

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STJA0006274
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Short Description :Mouse monoclonal anti-Corticotropin-releasing factor receptor 2 (50-150) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/ELISA
Host:Mouse
Reactivity:Human/Mouse/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :PTR1205
Conjugation:Unconjugated
Concentration:1 mg/mL
Purification:The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Dilution Range:WB 1:500-2000
Formulation:Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:CRHR2
Gene ID:1395
Uniprot ID:CRFR2_HUMAN
Immunogen:Synthesized peptide derived from human CRHR2 AA range: 50-150
Immunogen Region:50-150
Specificity:This antibody detects endogenous levels of CRHR2 at Human, Predict react with Mouse, Rat
Post Translational Modifications A N-glycosylation site within the signal peptide impedes its proper cleavage and function.
Function G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
Protein Name Corticotropin-Releasing Factor Receptor 2
Crf-R-2
Crf-R2
Crfr-2
Corticotropin-Releasing Hormone Receptor 2
Crh-R-2
Crh-R2
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-418555
Reactome: R-HSA-422085
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Corticotropin-Releasing Factor Receptor 2 antibody
Anti-Crf-R-2 antibody
Anti-Crf-R2 antibody
Anti-Crfr-2 antibody
Anti-Corticotropin-Releasing Hormone Receptor 2 antibody
Anti-Crh-R-2 antibody
Anti-Crh-R2 antibody
Anti-CRHR2 antibody
Anti-CRF2R antibody
Anti-CRH2R antibody

Information sourced from Uniprot.org

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