| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CRB1 |
| Gene ID: | 23418 |
| Uniprot ID: | CRUM1_HUMAN |
| Immunogen Region: | 28-133 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-133 of human CRB1 (NP_957705.1). |
| Immunogen Sequence: | NKNNTRCLSNSCQNNSTCKD FSKDNDCSCSDTANNLDKDC DNMKDPCFSNPCQGSATCVN TPGERSFLCKCPPGYSGTIC ETTIGSCGKNSCQHGGICHQ DPIYPV |
| Tissue Specificity | Preferential expression in retina, also expressed in brain, testis, fetal brain and fetal eye. Expressed at the outer limiting membrane and apical to adherens junctions in the retina. |
| Post Translational Modifications | Extensively glycosylated. |
| Function | Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion. |
| Protein Name | Protein Crumbs Homolog 1 |
| Cellular Localisation | Isoform 1: Apical Cell MembraneSingle-Pass Type I Membrane ProteinSecretedCell ProjectionCiliumPhotoreceptor Outer SegmentPhotoreceptor Inner SegmentIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Protein Crumbs Homolog 1 antibodyAnti-CRB1 antibody |
Information sourced from Uniprot.org