| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleavage and polyadenylation specificity factor subunit 7 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CPSF7 |
| Gene ID: |
79869 |
| Uniprot ID: |
CPSF7_HUMAN |
| Specificity: |
This antibody detects endogenous levels of CPSF7 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human CPSF7 |
| Function | Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF7 activates directly the mRNA 3'-processing machinery. Binds to pA signals in RNA substrates. |
| Protein Name | Cleavage And Polyadenylation Specificity Factor Subunit 7Cleavage And Polyadenylation Specificity Factor 59 Kda SubunitCpsf 59 Kda SubunitCleavage Factor Im Complex 59 Kda SubunitCfim59Pre-Mrna Cleavage Factor Im 59 Kda Subunit |
| Database Links | Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856Reactome: R-HSA-77595Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And The Cytoplasm In A Transcription- And Xpo1/Crm1-Independent MannerMost Probably In Complex With The Cleavage Factor Im Complex (Cfim) |
| Alternative Antibody Names | Anti-Cleavage And Polyadenylation Specificity Factor Subunit 7 antibodyAnti-Cleavage And Polyadenylation Specificity Factor 59 Kda Subunit antibodyAnti-Cpsf 59 Kda Subunit antibodyAnti-Cleavage Factor Im Complex 59 Kda Subunit antibodyAnti-Cfim59 antibodyAnti-Pre-Mrna Cleavage Factor Im 59 Kda Subunit antibodyAnti-CPSF7 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
