| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ceruloplasmin (680-790) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CP |
| Gene ID: |
1356 |
| Uniprot ID: |
CERU_HUMAN |
| Immunogen Region: |
680-790 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 680-790 of human Ceruloplasmin (NP_000087.1). |
| Immunogen Sequence: |
QTSLTLHMWPDTEGTFNVEC LTTDHYTGGMKQKYTVNQCR RQSEDSTFYLGERTYYIAAV EVEWDYSPQREWEKELHHLQ EQNVSNAFLDKGEFYIGSKY KKVVYRQYTDS |
| Tissue Specificity | Expressed by the liver and secreted in plasma. |
| Function | Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense. |
| Protein Name | CeruloplasminFerroxidase |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-425410Reactome: R-HSA-5619049Reactome: R-HSA-5619060Reactome: R-HSA-8957275Reactome: R-HSA-917937 |
| Cellular Localisation | SecretedColocalizes With Gcp1 In Secretory Intracellular Compartments |
| Alternative Antibody Names | Anti-Ceruloplasmin antibodyAnti-Ferroxidase antibodyAnti-CP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
