| Short Description : | Goat polyclonal antibody anti-COP1/PSEUDO-ICE-Isoform 2 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications: | Pep-ELISA/IF/FC |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.IF: Strong expression of the protein seen in the nuclei of U2OS cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of A549 cells. Recommended concentration: 10ug/ml. |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | CARD16 |
| Gene ID: | 114769 |
| Uniprot ID: | CAR16_HUMAN |
| Accession Number: | NP_443121.1 |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | ETLGLSAGPIPGN |
| Specificity: | This antibody is expected to recognize isoform 2 (NP_443121.1) only. In addition there may be cross-reaction with INCA (GeneID 440068; NP_001007233.1). |
| Function | Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
| Protein Name | Caspase Recruitment Domain-Containing Protein 16Caspase Recruitment Domain-Only Protein 1Card-Only Protein 1Caspase-1 Inhibitor CopPseudo Interleukin-1 Beta Converting EnzymePseudo-IcePseudo-Il1b-Converting Enzyme |
| Alternative Antibody Names | Anti-Caspase Recruitment Domain-Containing Protein 16 antibodyAnti-Caspase Recruitment Domain-Only Protein 1 antibodyAnti-Card-Only Protein 1 antibodyAnti-Caspase-1 Inhibitor Cop antibodyAnti-Pseudo Interleukin-1 Beta Converting Enzyme antibodyAnti-Pseudo-Ice antibodyAnti-Pseudo-Il1b-Converting Enzyme antibodyAnti-CARD16 antibodyAnti-COP antibodyAnti-COP1 antibody |
Information sourced from Uniprot.org
