| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COMMD5 |
| Gene ID: | 28991 |
| Uniprot ID: | COMD5_HUMAN |
| Immunogen Region: | 1-224 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-224 of human COMMD5 (NP_054785.2). |
| Immunogen Sequence: | MSAVGAATPYLHHPGDSHSG RVSFLGAQLPPEVAAMARLL GDLDRSTFRKLLKFVVSSLQ GEDCREAVQRLGVSANLPEE QLGALLAGMHTLLQQALRLP PTSLKPDTFRDQLQELCIPQ DLVGDLASVVFGSQRPLLDS VAQQQGAWLPHVADFRWRVD VAISTSALARSLQPSVLMQL KLSDGSAYRFEVPTAKFQEL RYSVALVLKEMADLEKRCER RLQD |
| Tissue Specificity | Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver. |
| Function | May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis. Down-regulates activation of NF-kappa-B. |
| Protein Name | Comm Domain-Containing Protein 5Hypertension-Related Calcium-Regulated Gene ProteinHcarg |
| Database Links | Reactome: R-HSA-8951664 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Comm Domain-Containing Protein 5 antibodyAnti-Hypertension-Related Calcium-Regulated Gene Protein antibodyAnti-Hcarg antibodyAnti-COMMD5 antibodyAnti-HT002 antibody |
Information sourced from Uniprot.org