| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | COL11A1 |
| Gene ID: | 1301 |
| Uniprot ID: | COBA1_HUMAN |
| Immunogen Region: | 260-430 |
| Immunogen Sequence: | EKKKSNFKKKMRTVATKSKE KSKKFTPPKSEKFSSKKKKS YQASAKAKLGVKANIVDDFQ EYNYGTMESYQTEAPRHVSG TNEPNPVEEIFTEEYLTGED YDSQRKNSEDTLYENKEIDG RDSDLLVDGDLGEYDFYEYK EYEDKPTSPPNEEFGPGVPA ETDITETSING |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-430 of human COL11A1 (NP_542196.2). |
| Tissue Specificity | Cartilage, placenta and some tumor or virally transformed cell lines. Isoforms using exon IIA or IIB are found in the cartilage while isoforms using only exon IIB are found in the tendon. |
| Post Translational Modifications | Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. N-glycosylated. |
| Function | May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils. |
| Protein Name | Collagen Alpha-1(Xi Chain |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1650814Reactome: R-HSA-2022090Reactome: R-HSA-3000171Reactome: R-HSA-8874081Reactome: R-HSA-8948216 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Collagen Alpha-1(Xi Chain antibodyAnti-COL11A1 antibodyAnti-COLL6 antibody |
Information sourced from Uniprot.org
