| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cannabinoid receptor 2 (191-240 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CNR2 |
| Gene ID: | 1269 |
| Uniprot ID: | CNR2_HUMAN |
| Immunogen Region: | 191-240 aa |
| Specificity: | CB2 Polyclonal Antibody detects endogenous levels of CB2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CNR2 at the amino acid range 191-240 |
| Post Translational Modifications | Constitutively phosphorylated on Ser-352.phosphorylation increases cell internalization and desensitizes the receptor. |
| Function | Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. |
| Protein Name | Cannabinoid Receptor 2Cb-2Cb2Hcb2Cx5 |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendritePerikaryonLocalizes To Apical Dendrite Of Pyramidal Neurons |
| Alternative Antibody Names | Anti-Cannabinoid Receptor 2 antibodyAnti-Cb-2 antibodyAnti-Cb2 antibodyAnti-Hcb2 antibodyAnti-Cx5 antibodyAnti-CNR2 antibodyAnti-CB2A antibodyAnti-CB2B antibody |
Information sourced from Uniprot.org