Anti-CNGB3 antibody (STJ190728)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Cyclic nucleotide-gated cation channel beta-3 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CNGB3 |
| Gene ID | 54714 |
| Uniprot ID | CNGB3_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | CNGB3 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Beta-3Cng Channel Beta-3Cone Photoreceptor Cgmp-Gated Channel Subunit BetaCyclic Nucleotide-Gated Cation Channel Beta-3Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Beta-3 antibodyAnti-Cng Channel Beta-3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Beta antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Beta-3 antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit antibodyAnti-CNGB3 antibody |
Information sourced from Uniprot.org