| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-CNGB3 (175-186) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:8000.IHC: In paraffin embedded Human Retina shows primarily staining of the pigmented epithelial cells. Recommended concentration: 2-4µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
CNGB3 |
| Gene ID: |
54714 |
| Uniprot ID: |
CNGB3_HUMAN |
| Immunogen Region: |
175-186 |
| Accession Number: |
NP_061971.3 |
| Immunogen Sequence: |
ESDDKPTEHYYR |
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Beta-3Cng Channel Beta-3Cone Photoreceptor Cgmp-Gated Channel Subunit BetaCyclic Nucleotide-Gated Cation Channel Beta-3Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Beta-3 antibodyAnti-Cng Channel Beta-3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Beta antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Beta-3 antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit antibodyAnti-CNGB3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
