Anti-CNGB3 antibody (C-Term) (STJ13100894)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the c-terminal region of human CNGB3 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CNGB3 (C-Term) for use in IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CNGB3 |
| Gene ID | 54714 |
| Uniprot ID | CNGB3_HUMAN |
| Immunogen | A synthetic peptide from the c-terminal region of human CNGB3 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | C-Term |
| Specificity | Specific for CNGB3. |
Additional Info
| Function | Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. |
| Protein Name | Cyclic Nucleotide-Gated Channel Beta-3Cng Channel Beta-3Cone Photoreceptor Cgmp-Gated Channel Subunit BetaCyclic Nucleotide-Gated Cation Channel Beta-3Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Beta-3 antibodyAnti-Cng Channel Beta-3 antibodyAnti-Cone Photoreceptor Cgmp-Gated Channel Subunit Beta antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Beta-3 antibodyAnti-Cyclic Nucleotide-Gated Cation Channel Modulatory Subunit antibodyAnti-CNGB3 antibody |
Information sourced from Uniprot.org