Anti-CNGA1 antibody (50-100 aa) (STJ13100882)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 50-100 of human CNGA1 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-CNGA1 (50-100 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | CNGA1 |
| Gene ID | 1259 |
| Uniprot ID | CNGA1_HUMAN |
| Immunogen | A synthetic peptide from aa region 50-100 of human CNGA1 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | 50-100 aa |
| Specificity | Specific for CNGA1. |
Additional Info
| Function | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-1Cng Channel Alpha-1Cng-1Cng1Cyclic Nucleotide-Gated Channel - PhotoreceptorRod Photoreceptor Cgmp-Gated Cation Channel Subunit AlphaCgmp-Gated Cation Channel Alpha-1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-1 antibodyAnti-Cng Channel Alpha-1 antibodyAnti-Cng-1 antibodyAnti-Cng1 antibodyAnti-Cyclic Nucleotide-Gated Channel - Photoreceptor antibodyAnti-Rod Photoreceptor Cgmp-Gated Cation Channel Subunit Alpha antibodyAnti-Cgmp-Gated Cation Channel Alpha-1 antibodyAnti-CNGA1 antibodyAnti-CNCG antibodyAnti-CNCG1 antibody |
Information sourced from Uniprot.org