| Host: |
Rabbit |
| Applications: |
IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Chemerin-like receptor 2 (121-170 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IF 1:200-1:1000ELISA 1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CMKLR2 |
| Gene ID: |
2825 |
| Uniprot ID: |
CML2_HUMAN |
| Immunogen Region: |
121-170 aa |
| Specificity: |
GPR1 Polyclonal Antibody detects endogenous levels of GPR1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GPR1 at the amino acid range 121-170 |
| Function | Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Acts also as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. (Microbial infection) Coreceptor for HIV-1. |
| Protein Name | Chemerin-Like Receptor 2Chemerin Chemokine-Like Receptor 2Chemokine-Like Receptor 2G-Protein Coupled Receptor 1 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes In Presence Of Its LigandTafa1Internalizes Efficiently In Response To Rarres2 |
| Alternative Antibody Names | Anti-Chemerin-Like Receptor 2 antibodyAnti-Chemerin Chemokine-Like Receptor 2 antibodyAnti-Chemokine-Like Receptor 2 antibodyAnti-G-Protein Coupled Receptor 1 antibodyAnti-CMKLR2 antibodyAnti-GPR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
