| Short Description : | Rabbit polyclonal anti-Chemerin-like receptor 2 (121-170 aa) for use in IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | IF 1:200-1:1000ELISA 1:5000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CMKLR2 |
| Gene ID: | 2825 |
| Uniprot ID: | CML2_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPR1 at the amino acid range 121-170 |
| Immunogen Region: | 121-170 aa |
| Specificity: | GPR1 Polyclonal Antibody detects endogenous levels of GPR1 protein. |
| Function | Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates weakly G proteins, calcium mobilization and MAPK1/MAPK3 (ERK1/2) phosphorylation too. Also acts as a receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway. (Microbial infection) Coreceptor for HIV-1. |
| Protein Name | Chemerin-Like Receptor 2Chemerin Chemokine-Like Receptor 2Chemokine-Like Receptor 2G-Protein Coupled Receptor 1 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes In Presence Of Its LigandTafa1Internalizes Efficiently In Response To Rarres2 |
| Alternative Antibody Names | Anti-Chemerin-Like Receptor 2 antibodyAnti-Chemerin Chemokine-Like Receptor 2 antibodyAnti-Chemokine-Like Receptor 2 antibodyAnti-G-Protein Coupled Receptor 1 antibodyAnti-CMKLR2 antibodyAnti-GPR1 antibody |
Information sourced from Uniprot.org
