Anti-CMKLR1 antibody [SAA1892] (STJA0020320)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Chemerin-Like Receptor 1 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1892 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | CMKLR1 |
| Gene ID | 1240 |
| Uniprot ID | CML1_HUMAN |
Additional Info
| Function | Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). |
| Protein Name | Chemerin-Like Receptor 1Chemokine-Like Receptor 1G-Protein Coupled Receptor Chemr23G-Protein Coupled Receptor Dez |
| Database Links | Reactome: R-HSA-373076 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinInternalizes Efficiently In Response To Rarres2 |
| Alternative Antibody Names | Anti-Chemerin-Like Receptor 1 antibodyAnti-Chemokine-Like Receptor 1 antibodyAnti-G-Protein Coupled Receptor Chemr23 antibodyAnti-G-Protein Coupled Receptor Dez antibodyAnti-CMKLR1 antibodyAnti-CHEMR23 antibodyAnti-DEZ antibody |
Information sourced from Uniprot.org