Anti-CMIP antibody (640-773) (STJ11103339)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CMIP (640-773) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CMIP |
| Gene ID | 80790 |
| Uniprot ID | CMIP_HUMAN |
| Immunogen Region | 640-773 |
| Immunogen Sequence | RLTLPSKSTDADLARLLSSG SFGNLENLSLAFTNVTSACA EHLIKLPSLKQLNLWSTQFG DAGLRLLSEHLTMLQVLNLC ETPVTDAGLLALSSMKSLCS LNMNSTKLSADTYEDLKAKL PNLKEVDVRYTEAW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 640-773 of human CMIP (NP_938204.2). |
Additional Info
| Tissue Specificity | Isoform 1 is expressed in peripheral blood mononuclear cells and kidney. Lower expression in brain and liver. Expression is down-regulated in activated cells. Isoform 2 is expressed in lymphocyte precursors, however, expression shuts down during maturation and differentiation in thymus and fetal liver. |
| Function | Plays a role in T-cell signaling pathway. Isoform 2 may play a role in T-helper 2 (Th2) signaling pathway and seems to represent the first proximal signaling protein that links T-cell receptor-mediated signal to the activation of c-Maf Th2 specific factor. |
| Protein Name | C-Maf-Inducing ProteinC-MipTruncated C-Maf-Inducing ProteinTc-Mip |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmIsoform 2 Is Translocated To The Nucleus And Is Specifically Recruited During Minimal Change Nephrotic Syndrome (Mcns)Detected In Nuclear And Cytoplasmic Compartments During Mcns RelapseExpressed In Cytoplasm Only During Mcns Remission And Absent In Normal Patients |
| Alternative Antibody Names | Anti-C-Maf-Inducing Protein antibodyAnti-C-Mip antibodyAnti-Truncated C-Maf-Inducing Protein antibodyAnti-Tc-Mip antibodyAnti-CMIP antibodyAnti-KIAA1694 antibodyAnti-TCMIP antibody |
Information sourced from Uniprot.org