Anti-CLSTN2 antibody (494-544 aa) (STJ193695)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CSTN2 at the amino acid range 494-544
General Information
| Short Description | Rabbit polyclonal anti-Calsyntenin-2 (494-544 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLSTN2 |
| Gene ID | 64084 |
| Uniprot ID | CSTN2_HUMAN |
| Immunogen | Synthesized peptide derived from the human CSTN2 at the amino acid range 494-544 |
| Immunogen Region | 494-544 aa |
| Specificity | This antibody detects endogenous levels of CSTN2 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Proteolytically processed under normal cellular conditions. A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1). A secondary cleavage catalyzed by gamma-secretase within the transmembrane domain releases the beta-Alc-gamma chain in the extracellular milieu and produces an intracellular fragment (AlcICD). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1. |
| Function | Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. |
| Protein Name | Calsyntenin-2Alcadein-GammaAlc-Gamma |
| Database Links | |
| Cellular Localisation | Postsynaptic Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneGolgi Apparatus MembraneCell ProjectionDendriteMost Prominent In The Postsynaptic Specializations Of Asymmetric (Type I) Synapses With Both Axodendritic And Axospinous Localization |
| Alternative Antibody Names | Anti-Calsyntenin-2 antibodyAnti-Alcadein-Gamma antibodyAnti-Alc-Gamma antibodyAnti-CLSTN2 antibodyAnti-CS2 antibody |
Information sourced from Uniprot.org