| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLEC12A (66-265) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLEC12A |
| Gene ID: |
160364 |
| Uniprot ID: |
CL12A_HUMAN |
| Immunogen Region: |
66-265 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 66-265 of human CLEC12A (NP_612210.4). |
| Immunogen Sequence: |
VTLKIEMKKMNKLQNISEEL QRNISLQLMSNMNISNKIRN LSTTLQTIATKLCRELYSKE QEHKCKPCPRRWIWHKDSCY FLSDDVQTWQESKMACAAQN ASLLKINNKNALEFIKSQSR SYDYWLGLSPEEDSTRGMRV DNIINSSAWVIRNAPDLNNM YCGYINRLYVQYYHCTYKKR MICEKMANPVQLGSTYFREA |
| Tissue Specificity | Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. |
| Post Translational Modifications | Highly N-glycosylated. Glycosylation varies between cell types. |
| Function | Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. |
| Protein Name | C-Type Lectin Domain Family 12 Member AC-Type Lectin-Like Molecule 1Cll-1Dendritic Cell-Associated Lectin 2Dcal-2Myeloid Inhibitory C-Type Lectin-Like ReceptorMiclCd Antigen Cd371 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLigand Binding Leads To Internalization |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 12 Member A antibodyAnti-C-Type Lectin-Like Molecule 1 antibodyAnti-Cll-1 antibodyAnti-Dendritic Cell-Associated Lectin 2 antibodyAnti-Dcal-2 antibodyAnti-Myeloid Inhibitory C-Type Lectin-Like Receptor antibodyAnti-Micl antibodyAnti-Cd Antigen Cd371 antibodyAnti-CLEC12A antibodyAnti-CLL1 antibodyAnti-DCAL2 antibodyAnti-MICL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
