| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Monkey |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Cleaved-Integrin alpha-7-E959 (940-989 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ITGA7 |
| Gene ID: |
3679 |
| Uniprot ID: |
ITA7_HUMAN |
| Immunogen Region: |
940-989 aa |
| Specificity: |
Cleaved-Integrin Alpha 7 LC (E959) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin Alpha 7 LC protein resulting from cleavage adjacent to E959. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ITGA7 at the amino acid range 940-989 |
| Post Translational Modifications | ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes. A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin. |
| Function | Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. |
| Protein Name | Integrin Alpha-7 Cleaved Into - Integrin Alpha-7 Heavy Chain - Integrin Alpha-7 Light Chain - Integrin Alpha-7 70 Kda Form |
| Database Links | Reactome: R-HSA-216083Reactome: R-HSA-3000157Reactome: R-HSA-3000178 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-7 Cleaved Into - Integrin Alpha-7 Heavy Chain - Integrin Alpha-7 Light Chain - Integrin Alpha-7 70 Kda Form antibodyAnti-ITGA7 antibodyAnti-UNQ406 antibodyAnti-PRO768 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
