Anti-CLDN10 antibody (1-100) (STJ111895)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CLDN10 (1-100) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CLDN10 |
| Gene ID | 9071 |
| Uniprot ID | CLD10_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MASTASEIIAFMVSISGWVL VSSTLPTDYWKVSTIDGTVI TTATYWANLWKACVTDSTGV SNCKDFPSMLALDGYIQACR GLMIAAVSLGFFGSIFALFG |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CLDN10 (NP_008915.1). |
Additional Info
| Tissue Specificity | Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the clear cells. |
| Function | Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. Isoform 1: Forms cation-selective paracellular channels. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function. Isoform 2: Forms anion-selective paracellular channels. In renal proximal tubules, it conveys selective chloride over hydrogencarbonate anion permeability which is required for renal chloride reabsorption and salt homeostasis. |
| Protein Name | Claudin-10Oligodendrocyte-Specific Protein-LikeOsp-Like |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Isoform 1: Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinIsoform 2: Cell Junction |
| Alternative Antibody Names | Anti-Claudin-10 antibodyAnti-Oligodendrocyte-Specific Protein-Like antibodyAnti-Osp-Like antibodyAnti-CLDN10 antibody |
Information sourced from Uniprot.org