| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CLCNKA (470-644) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLCNKA |
| Gene ID: |
1187 |
| Uniprot ID: |
CLCKA_HUMAN |
| Immunogen Region: |
470-644 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 470-644 of human CLCNKA (NP_001244068.1). |
| Immunogen Sequence: |
QSCQPSFYDGTIIVKKLPYL PRILGRNIGSHHVRVEHFMN HSITTLAKDTPLEEVVKVVT STDVTEYPLVESTESQILVG IVQRAQLVQALQAEPPSRAP GHQQCLQDILARGCPTEPVT LTLFSETTLHQAQNLFKLLN LQSLFVTSRGRAVGCVSWVE MKKAISNLTNPPAPK |
| Tissue Specificity | Expressed predominantly in the kidney. All nephron segments expressing BSND also express CLCNK proteins. |
| Function | Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume.membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. |
| Protein Name | Chloride Channel Protein Clc-KaChloride Channel KaClc-K1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Chloride Channel Protein Clc-Ka antibodyAnti-Chloride Channel Ka antibodyAnti-Clc-K1 antibodyAnti-CLCNKA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TTLL12 knockout (KO) 293T cells, using [KO Validated] TTLL12 Rabbit polyclonal antibody (STJ11100870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89804/358271/STJ11100870_1__29815.1713122614.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TTLL12 knockout (KO) 293T cells, using [KO Validated] TTLL12 Rabbit polyclonal antibody (STJ11100870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
