| Post Translational Modifications | Cleaved into 2 chains possibly by a furin-like protease upon or preceding secretion. |
| Function | Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage. |
| Protein Name | Cartilage Intermediate Layer Protein 1Cilp-1Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 |
| Database Links | Reactome: R-HSA-2404192 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Cartilage Intermediate Layer Protein 1 antibodyAnti-Cilp-1 antibodyAnti-Cartilage Intermediate-Layer Protein Cleaved Into - Cartilage Intermediate Layer Protein 1 C1 - Cartilage Intermediate Layer Protein 1 C2 antibodyAnti-CILP antibodyAnti-UNQ602 antibodyAnti-PRO1188 antibody |
Information sourced from Uniprot.org
