• Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CIDEC Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of HeLa cells, using CIDEC Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-CIDEC antibody (189-238 aa) (STJ92292)

SKU:
STJ92292

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Lipid transferase CIDEC (189-238 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:5000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CIDEC
Gene ID: 63924
Uniprot ID: CIDEC_HUMAN
Immunogen Region: 189-238 aa
Specificity: CIDE-3 Polyclonal Antibody detects endogenous levels of CIDE-3 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CIDEC at the amino acid range 189-238
Post Translational Modifications Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation.
Function Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion. Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage. Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment.
Protein Name Lipid Transferase Cidec
Cell Death Activator Cide-3
Cell Death-Inducing Dffa-Like Effector Protein C
Fat-Specific Protein Fsp27 Homolog
Database Links Reactome: R-HSA-8963889 Q96AQ7-1
Reactome: R-HSA-8964572
Cellular Localisation Lipid Droplet
Endoplasmic Reticulum
Nucleus
Diffuses Quickly On Lipid Droplet Surface
But Becomes Trapped And Clustered At Lipid Droplet Contact Sites
Thereby Enabling Its Rapid Enrichment At Lipid Droplet Contact Sites
Alternative Antibody Names Anti-Lipid Transferase Cidec antibody
Anti-Cell Death Activator Cide-3 antibody
Anti-Cell Death-Inducing Dffa-Like Effector Protein C antibody
Anti-Fat-Specific Protein Fsp27 Homolog antibody
Anti-CIDEC antibody
Anti-FSP27 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance