| Short Description : | Rabbit polyclonal CIAPIN1 (1-312) antibody for use in WB, IF, ICC, IP and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CIAPIN1 |
| Gene ID: | 57019 |
| Uniprot ID: | CPIN1_HUMAN |
| Immunogen Region: | 1-312 |
| Immunogen Sequence: | MADFGISAGQFVAVVWDKSS PVEALKGLVDKLQALTGNEG RVSVENIKQLLQSAHKESSF DIILSGLVPGSTTLHSAEIL AEIARILRPGGCLFLKEPVE TAVDNNSKVKTASKLCSALT LSGLVEVKELQREPLTPEEV QSVREHLGHESDNLLFVQIT GKKPNFEVGSSRQLKLSITK KSSPSVKPAVDPAAAKLWTL SANDMEDDSMDLIDSDELLD PEDLKKPDPASLRAASCGE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-312 of human CIAPIN1 (NP_064709.2). |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in heart, liver and pancreas. |
| Function | Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a 4Fe-4S cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. |
| Protein Name | AnamorsinCytokine-Induced Apoptosis Inhibitor 1Fe-S Cluster Assembly Protein Dre2 Homolog |
| Database Links | Reactome: R-HSA-2564830 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Intermembrane Space |
| Alternative Antibody Names | Anti-Anamorsin antibodyAnti-Cytokine-Induced Apoptosis Inhibitor 1 antibodyAnti-Fe-S Cluster Assembly Protein Dre2 Homolog antibodyAnti-CIAPIN1 antibodyAnti-CUA001 antibodyAnti-PRO0915 antibody |
Information sourced from Uniprot.org
