| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit ->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1-> within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain. Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking. Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures. |
| Protein Name | Carbohydrate Sulfotransferase 1Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1Gst-1Keratan Sulfate Gal-6 SulfotransferaseKs6stKsgal6stKsst |
| Database Links | Reactome: R-HSA-2022854 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 1 antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 1 antibodyAnti-Gst-1 antibodyAnti-Keratan Sulfate Gal-6 Sulfotransferase antibodyAnti-Ks6st antibodyAnti-Ksgal6st antibodyAnti-Ksst antibodyAnti-CHST1 antibody |
Information sourced from Uniprot.org
