| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CHGB |
| Gene ID: | 1114 |
| Uniprot ID: | SCG1_HUMAN |
| Immunogen Region: | 550-650 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 550-650 of human Chromogranin B (P05060). |
| Immunogen Sequence: | EEENELTLNEKNFFPEYNYD WWEKKPFSEDVNWGYEKRNL ARVPKLDLKRQYDRVAQLDQ LLHYRKKSAEFPDFYDSEEP VSTHQEAENEKDRADQTVLT E |
| Tissue Specificity | Detected in cerebrospinal fluid and urine (at protein level). Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. |
| Post Translational Modifications | Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues. O-glycosylated. |
| Function | Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. |
| Protein Name | Secretogranin-1Chromogranin-BCgbSecretogranin ISgi Cleaved Into - Pe-11 - Gawk Peptide - Ccb Peptide |
| Database Links | Reactome: R-HSA-381426Reactome: R-HSA-8957275 |
| Cellular Localisation | SecretedNeuroendocrine And Endocrine Secretory Granules |
| Alternative Antibody Names | Anti-Secretogranin-1 antibodyAnti-Chromogranin-B antibodyAnti-Cgb antibodyAnti-Secretogranin I antibodyAnti-Sgi Cleaved Into - Pe-11 - Gawk Peptide - Ccb Peptide antibodyAnti-CHGB antibodyAnti-SCG1 antibody |
Information sourced from Uniprot.org