| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-COPA (550-650) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
COPA |
| Gene ID: |
1314 |
| Uniprot ID: |
COPA_HUMAN |
| Immunogen Region: |
550-650 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human COPA (NP_001091868.1). |
| Immunogen Sequence: |
FIYTTSNHIKYAVTTGDHGI IRTLDLPIYVTRVKGNNVYC LDRECRPRVLTIDPTEFKFK LALINRKYDEVLHMVRNAKL VGQSIIAYLQKKGYPEVALH F |
| Tissue Specificity | Uniformly expressed in a wide range of adult and fetal tissues. Xenin is found in gastric, duodenal and jejunal mucosa. Circulates in the blood. Seems to be confined to specific endocrine cells. |
| Function | The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins.the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Xenin stimulates exocrine pancreatic secretion. It inhibits pentagastrin-stimulated secretion of acid, to induce exocrine pancreatic secretion and to affect small and large intestinal motility. In the gut, xenin interacts with the neurotensin receptor. |
| Protein Name | Coatomer Subunit AlphaAlpha-Coat ProteinAlpha-CopHep-CopHepcop Cleaved Into - XeninXenopsin-Related Peptide - Proxenin |
| Database Links | Reactome: R-HSA-6807878Reactome: R-HSA-6811434 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinCytoplasmic SideCytoplasmic VesicleCopi-Coated Vesicle MembraneThe Coatomer Is Cytoplasmic Or Polymerized On The Cytoplasmic Side Of The GolgiAs Well As On The Vesicles/Buds Originating From ItXenin: Secreted |
| Alternative Antibody Names | Anti-Coatomer Subunit Alpha antibodyAnti-Alpha-Coat Protein antibodyAnti-Alpha-Cop antibodyAnti-Hep-Cop antibodyAnti-Hepcop Cleaved Into - Xenin antibodyAnti-Xenopsin-Related Peptide - Proxenin antibodyAnti-COPA antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
