| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CHD6 |
| Gene ID: |
84181 |
| Uniprot ID: |
CHD6_HUMAN |
| Immunogen Region: |
1850-2070 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1850-2070 of human CHD6 (NP_115597.3). |
| Immunogen Sequence: |
NKSLESKLILSQNHSDEEEE EEENEEENLAMAVGMGERPE VLHLTEPTTNISREKNQGFQ DETKKGSLEVANQTPGLQRA FPAPAACQCHCKHMERWMHG LENDEFEIEKPKAYIPDLFK SKTNTIAMEGEPTAIPSQPF KVKHELLKEPWKESAEGQNV FPTYPLEGSELKSEDMDFEN KDDYDRDGNCHSQDYPGKYS EEESKSSTSGITGDIGDELQ E |
| Tissue Specificity | Widely expressed. |
| Function | DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 6Chd-6Atp-Dependent Helicase Chd6Radiation-Induced Gene B Protein |
| Cellular Localisation | NucleusNucleoplasmEnriched At Sites Of Mrna SynthesisDuring Influenza A Virus InfectionLocalizes To Inactive Chromatin |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 6 antibodyAnti-Chd-6 antibodyAnti-Atp-Dependent Helicase Chd6 antibodyAnti-Radiation-Induced Gene B Protein antibodyAnti-CHD6 antibodyAnti-CHD5 antibodyAnti-KIAA1335 antibodyAnti-RIGB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
