Anti-CHD1 antibody (960-1040 aa) (STJ190179)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 960-1040
General Information
| Short Description | Rabbit polyclonal anti-Chromodomain-helicase-DNA-binding protein 1 (960-1040 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CHD1 |
| Gene ID | 1105 |
| Uniprot ID | CHD1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 960-1040 |
| Immunogen Region | 960-1040 aa |
| Specificity | CHD1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. Is also associated with histone deacetylase (HDAC) activity. Required for the bridging of SNF2, the FACT complex, the PAF complex as well as the U2 snRNP complex to H3K4me3. Functions to modulate the efficiency of pre-mRNA splicing in part through physical bridging of spliceosomal components to H3K4me3. Required for maintaining open chromatin and pluripotency in embryonic stem cells. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1Chd-1Atp-Dependent Helicase Chd1 |
| Database Links | Reactome: R-HSA-9018519 |
| Cellular Localisation | NucleusCytoplasmIs Released Into The Cytoplasm When Cells Enter Mitosis And Is Reincorporated Into Chromatin During Telophase-Cytokinesis |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1 antibodyAnti-Chd-1 antibodyAnti-Atp-Dependent Helicase Chd1 antibodyAnti-CHD1 antibody |
Information sourced from Uniprot.org