| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cFLIP (90-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CFLAR |
| Gene ID: |
8837 |
| Uniprot ID: |
CFLAR_HUMAN |
| Immunogen Region: |
90-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-240 of human cFLIP (NP_003870.4). |
| Immunogen Sequence: |
VSDYRVLMAEIGEDLDKSDV SSLIFLMKDYMGRGKISKEK SFLDLVVELEKLNLVAPDQL DLLEKCLKNIHRIDLKTKIQ KYKQSVQGAGTSYRNVLQAA IQKSLKDPSNNFRLHNGRSK EQRLKEQLGAQQEPVKKSIQ ESEAFLPQSIP |
| Tissue Specificity | Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle. |
| Post Translational Modifications | Proteolytically processed by CASP8 generating subunit p43 and p12. |
| Function | Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. |
| Protein Name | Casp8 And Fadd-Like Apoptosis RegulatorCaspase HomologCashCaspase-Eight-Related ProteinCasperCaspase-Like Apoptosis Regulatory ProteinClarpCellular Flice-Like Inhibitory ProteinC-FlipFadd-Like Antiapoptotic Molecule 1Flame-1Inhibitor Of FliceI-FliceMach-Related Inducer Of ToxicityMritUsurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 |
| Database Links | Reactome: R-HSA-3371378 O15519-1Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-5357905 O15519-1Reactome: R-HSA-69416 O15519-2Reactome: R-HSA-75158 |
| Alternative Antibody Names | Anti-Casp8 And Fadd-Like Apoptosis Regulator antibodyAnti-Caspase Homolog antibodyAnti-Cash antibodyAnti-Caspase-Eight-Related Protein antibodyAnti-Casper antibodyAnti-Caspase-Like Apoptosis Regulatory Protein antibodyAnti-Clarp antibodyAnti-Cellular Flice-Like Inhibitory Protein antibodyAnti-C-Flip antibodyAnti-Fadd-Like Antiapoptotic Molecule 1 antibodyAnti-Flame-1 antibodyAnti-Inhibitor Of Flice antibodyAnti-I-Flice antibodyAnti-Mach-Related Inducer Of Toxicity antibodyAnti-Mrit antibodyAnti-Usurpin Cleaved Into - Casp8 And Fadd-Like Apoptosis Regulator Subunit P43 - Casp8 And Fadd-Like Apoptosis Regulator Subunit P12 antibodyAnti-CFLAR antibodyAnti-CASH antibodyAnti-CASP8AP1 antibodyAnti-CLARP antibodyAnti-MRIT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
