| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CFL2 |
| Gene ID: | 1073 |
| Uniprot ID: | COF2_HUMAN |
| Immunogen Region: | 1-166 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-166 of human CFL2 (NP_068733.1). |
| Immunogen Sequence: | MASGVTVNDEVIKVFNDMKV RKSSTQEEIKKRKKAVLFCL SDDKRQIIVEEAKQILVGDI GDTVEDPYTSFVKLLPLNDC RYALYDATYETKESKKEDLV FIFWAPESAPLKSKMIYASS KDAIKKKFTGIKHEWQVNGL DDIKDRSTLGEKLGGNVVVS LEGKPL |
| Tissue Specificity | Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. |
| Post Translational Modifications | The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. |
| Function | Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere. |
| Protein Name | Cofilin-2Cofilin - Muscle Isoform |
| Cellular Localisation | Nucleus MatrixCytoplasmCytoskeletonColocalizes With Cspr3 In The Z Line Of Sarcomeres |
| Alternative Antibody Names | Anti-Cofilin-2 antibodyAnti-Cofilin - Muscle Isoform antibodyAnti-CFL2 antibody |
Information sourced from Uniprot.org
