| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CES1 (287-566) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CES1 |
| Gene ID: |
1066 |
| Uniprot ID: |
EST1_HUMAN |
| Immunogen Region: |
287-566 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 287-566 of human CES1 (NP_001257.4). |
| Immunogen Sequence: |
RQKTEEELLETTLKMKFLSL DLQGDPRESQPLLGTVIDGM LLLKTPEELQAERNFHTVPY MVGINKQEFGWLIPMLMSYP LSEGQLDQKTAMSLLWKSYP LVCIAKELIPEATEKYLGGT DDTVKKKDLFLDLIADVMFG VPSVIVARNHRDAGAPTYMY EFQYRPSFSSDMKPKTVIGD HGDELFSVFGAPFLKEGASE EEIRLSKMVMKFWANFARNG NPNGEGLPHWPEYNQKEGY |
| Tissue Specificity | Expressed predominantly in liver with lower levels in heart and lung. Expressed in macrophages. |
| Post Translational Modifications | Contains sialic acid. Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19. |
| Function | Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate. Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins. Hydrolyzes cellular cholesteryl esters to free cholesterols and promotes reverse cholesterol transport (RCT) by facilitating both the initial and final steps in the process. First of all, allows free cholesterol efflux from macrophages to extracellular cholesterol acceptors and secondly, releases free cholesterol from lipoprotein-delivered cholesteryl esters in the liver for bile acid synthesis or direct secretion into the bile. |
| Protein Name | Liver Carboxylesterase 1Acyl-Coenzyme A -Cholesterol AcyltransferaseAcatBrain Carboxylesterase Hbr1Carboxylesterase 1Ce-1Hce-1Cholesteryl Ester HydrolaseCehCocaine CarboxylesteraseEgasynHmseMethylumbelliferyl-Acetate Deacetylase 1Monocyte/Macrophage Serine EsteraseRetinyl Ester HydrolaseRehSerine Esterase 1Triacylglycerol HydrolaseTgh |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-211945Reactome: R-HSA-5578768Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum LumenCytoplasmLipid DropletMoves From Cytoplasm To Lipid Droplets Upon Lipid LoadingAssociates With Lipid Droplets Independently Of Triglycerides (Tg) Content Of The Droplets And Hydrolyzes Cholesteryl Esters More Efficiently From Mixed Droplets |
| Alternative Antibody Names | Anti-Liver Carboxylesterase 1 antibodyAnti-Acyl-Coenzyme A -Cholesterol Acyltransferase antibodyAnti-Acat antibodyAnti-Brain Carboxylesterase Hbr1 antibodyAnti-Carboxylesterase 1 antibodyAnti-Ce-1 antibodyAnti-Hce-1 antibodyAnti-Cholesteryl Ester Hydrolase antibodyAnti-Ceh antibodyAnti-Cocaine Carboxylesterase antibodyAnti-Egasyn antibodyAnti-Hmse antibodyAnti-Methylumbelliferyl-Acetate Deacetylase 1 antibodyAnti-Monocyte/Macrophage Serine Esterase antibodyAnti-Retinyl Ester Hydrolase antibodyAnti-Reh antibodyAnti-Serine Esterase 1 antibodyAnti-Triacylglycerol Hydrolase antibodyAnti-Tgh antibodyAnti-CES1 antibodyAnti-CES2 antibodyAnti-SES1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
