| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RNF220 (267-566) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF220 |
| Gene ID: |
55182 |
| Uniprot ID: |
RN220_HUMAN |
| Immunogen Region: |
267-566 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 267-566 of human RNF220 (NP_060620.2). |
| Immunogen Sequence: |
PKSLLLSASIKREGESPTAS PHSSATDDLHHSDRYQTFLR VRANRQTRLNARIGKMKRRK QDEGQREGSCMAEDDAVDIE HENNNRFEEYEWCGQKRIRA TTLLEGGFRGSGFIMCSGKE NPDSDADLDVDGDDTLEYGK PQYTEADVIPCTGEEPGEAK EREALRGAVLNGGPPSTRIT PEFSKWASDEMPSTSNGESS KQEAMQKTCKNSDIEKITED SAVTTFEALKARVRELERQ |
| Tissue Specificity | Ubiquitously expressed. Abundant in brain and spinal cord, particularly in the cerebellum and cerebral cortex. In fetal tissues expressed in the cerebellum, spinal cord and cortex. |
| Post Translational Modifications | Auto-ubiquitinated.leads to proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling. Plays a critical role in the regulation of nuclear lamina. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf220Ring Finger Protein 220Ring-Type E3 Ubiquitin Transferase Rnf220 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf220 antibodyAnti-Ring Finger Protein 220 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rnf220 antibodyAnti-RNF220 antibodyAnti-C1orf164 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
