| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CELA2A |
| Gene ID: | 63036 |
| Uniprot ID: | CEL2A_HUMAN |
| Immunogen Region: | 80-150 |
| Immunogen Sequence: | TYRVGLGRHNLYVAESGSLA VSVSKIVVHKDWNSNQISKG NDIALLKLANPVSLTDKIQL ACLPPAGTILP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-150 of human CELA2A (NP_254275.1). |
| Tissue Specificity | Expressed in pancreas. Not detected in keratinocytes. Detected in exocrine secretions of the pancreas (at protein level). Also expressed in a small fraction of cells in pancreatic islets, adrenal cortex, intestinal glands and colonic lymphoid follicles (at protein level). Detected in plasma. |
| Function | Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. |
| Protein Name | Chymotrypsin-Like Elastase Family Member 2aElastase-2a |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9925561 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Chymotrypsin-Like Elastase Family Member 2a antibodyAnti-Elastase-2a antibodyAnti-CELA2A antibodyAnti-ELA2A antibody |
Information sourced from Uniprot.org
