| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CEACAM5 |
| Gene ID: | 1048 |
| Uniprot ID: | CEAM5_HUMAN |
| Immunogen Region: | 1-702 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-702 of human CEACAM5 (P06731). |
| Immunogen Sequence: | MESPSAPPHRWCIPWQRLLL TASLLTFWNPPTTAKLTIES TPFNVAEGKEVLLLVHNLPQ HLFGYSWYKGERVDGNRQII GYVIGTQQATPGPAYSGREI IYPNASLLIQNIIQNDTGFY TLHVIKSDLVNEEATGQFRV YPELPKPSISSNNSKPVEDK DAVAFTCEPETQDATYLWWV NNQSLPVSPRLQLSNGNRTL TLFNVTRNDTASYKCETQNP VSARRSDSVILNVLYGPDA |
| Tissue Specificity | Expressed in columnar epithelial and goblet cells of the colon (at protein level). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. |
| Post Translational Modifications | Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. |
| Function | Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression.induces resistance to anoikis of colorectal carcinoma cells. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. |
| Protein Name | Cell Adhesion Molecule Ceacam5 Carcinoembryonic Antigen Cea Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Cea Cell Adhesion Molecule 5 Meconium Antigen 100 Cd Antigen Cd66e |
| Database Links | Reactome: R-HSA-163125 Reactome: R-HSA-202733 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Apical Cell Membrane Cell Surface Localized To The Apical Glycocalyx Surface |
| Alternative Antibody Names | Anti-Cell Adhesion Molecule Ceacam5 antibody Anti-Carcinoembryonic Antigen antibody Anti-Cea antibody Anti-Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 antibody Anti-Cea Cell Adhesion Molecule 5 antibody Anti-Meconium Antigen 100 antibody Anti-Cd Antigen Cd66e antibody Anti-CEACAM5 antibody Anti-CEA antibody |
Information sourced from Uniprot.org