Anti-CD95/FAS antibody [HFE7A] {FITC} (STJA0028359)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationFITC
IsotypeIgG1k
General Information
| Short Description | Rat monoclonal Tumor Necrosis Factor Receptor Superfamily Member 6 antibody for use in ELISA, FC and WB in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/WB |
| Host | Rat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HFE7A |
| Isotype | IgG1k |
| Conjugation | FITC |
| Concentration | 05 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months Protect from light Do not freeze |
Target Information
| Gene Symbol | Fas |
| Gene ID | 14102 |
| Uniprot ID | TNR6_MOUSE |
Additional Info
| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 6Apo-1 AntigenApoptosis-Mediating Surface Antigen FasFaslg ReceptorCd Antigen Cd95 |
| Database Links | Reactome: R-MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-69416Reactome: -MMU-75157 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 6 antibodyAnti-Apo-1 Antigen antibodyAnti-Apoptosis-Mediating Surface Antigen Fas antibodyAnti-Faslg Receptor antibodyAnti-Cd Antigen Cd95 antibodyAnti-Fas antibodyAnti-Apt1 antibodyAnti-Tnfrsf6 antibody |
Information sourced from Uniprot.org