Anti-CD79B antibody (61-110 aa) (STJ96620)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD79B at the amino acid range 61-110
General Information
| Short Description | Rabbit polyclonal anti-B-cell antigen receptor complex-associated protein beta chain (61-110 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CD79B |
| Gene ID | 974 |
| Uniprot ID | CD79B_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human CD79B at the amino acid range 61-110 |
| Immunogen Region | 61-110 aa |
| Specificity | CD79b Polyclonal Antibody detects endogenous levels of CD79b protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. |
| Function | Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. |
| Protein Name | B-Cell Antigen Receptor Complex-Associated Protein Beta ChainB-Cell-Specific Glycoprotein B29Ig-BetaImmunoglobulin-Associated B29 ProteinCd Antigen Cd79b |
| Database Links | Reactome: R-HSA-5690714Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinFollowing Antigen BindingThe Bcr Has Been Shown To Translocate From Detergent-Soluble Regions Of The Cell Membrane To Lipid Rafts Although Signal Transduction Through The Complex Can Also Occur Outside Lipid Rafts |
| Alternative Antibody Names | Anti-B-Cell Antigen Receptor Complex-Associated Protein Beta Chain antibodyAnti-B-Cell-Specific Glycoprotein B29 antibodyAnti-Ig-Beta antibodyAnti-Immunoglobulin-Associated B29 Protein antibodyAnti-Cd Antigen Cd79b antibodyAnti-CD79B antibodyAnti-B29 antibodyAnti-IGB antibody |
Information sourced from Uniprot.org