| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Cd68 |
| Gene ID: | 12514 |
| Uniprot ID: | CD68_MOUSE |
| Immunogen Region: | 50-150 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of mouse CD68 (NP_001277987.1). |
| Immunogen Sequence: | SHRPTTTSHGNVTVHTSSGP TTVTHNPATTTSHGNATISH ATVSPTTNGTATSPRSSTVG PHPGPPPPSPSPRSKGALGN YTWANGSQPCVQLQAQIQIR I |
| Tissue Specificity | Expressed in tissue macrophages and to a lesser extent in dendritic cells. |
| Post Translational Modifications | N- and O-glycosylated. |
| Function | Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. |
| Protein Name | MacrosialinCd Antigen Cd68 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Isoform Long: Endosome MembraneSingle-Pass Type I Membrane ProteinLysosome MembraneIsoform Short: Cell Membrane |
| Alternative Antibody Names | Anti-Macrosialin antibodyAnti-Cd Antigen Cd68 antibodyAnti-Cd68 antibody |
Information sourced from Uniprot.org