Anti-KCNJ5 antibody (50-150) (STJ27988)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal KCNJ5 (50-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | KCNJ5 |
| Gene ID | 3762 |
| Uniprot ID | KCNJ5_HUMAN |
| Immunogen Region | 50-150 |
| Immunogen Sequence | RQRYMEKSGKCNVHHGNVQE TYRYLSDLFTTLVDLKWRFN LLVFTMVYTVTWLFFGFIWW LIAYIRGDLDHVGDQEWIPC VENLSGFVSAFLFSIETETT I |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human KCNJ5 (NP_000881.3). |
Additional Info
| Tissue Specificity | Islets, exocrine pancreas and heart. Expressed in the adrenal cortex, particularly the zona glomerulosa. |
| Function | Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium.as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins. |
| Protein Name | G Protein-Activated Inward Rectifier Potassium Channel 4Girk-4Cardiac Inward RectifierCirHeart Katp ChannelInward Rectifier K(+ Channel Kir3.4Irk-4Katp-1Potassium Channel - Inwardly Rectifying Subfamily J Member 5 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-997272 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-G Protein-Activated Inward Rectifier Potassium Channel 4 antibodyAnti-Girk-4 antibodyAnti-Cardiac Inward Rectifier antibodyAnti-Cir antibodyAnti-Heart Katp Channel antibodyAnti-Inward Rectifier K(+ Channel Kir3.4 antibodyAnti-Irk-4 antibodyAnti-Katp-1 antibodyAnti-Potassium Channel - Inwardly Rectifying Subfamily J Member 5 antibodyAnti-KCNJ5 antibodyAnti-GIRK4 antibody |
Information sourced from Uniprot.org