Host: | Goat |
Applications: | WB/IHC-F/IHC-P/IF |
Reactivity: | Human/Rat/Mouse/Monkey/Canine |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Goat polyclonal antibody anti-Lysosome-associated membrane glycoprotein 3 (120aa to 175aa) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
Purification: | This antibody is epitope-affinity purified from goat antiserum. |
Concentration: | 3 mg/mL |
Dilution Range: | WB 1:500-1:5000 IF 1:25-1:250 IHC-F 1:250-1:1000 IHC-P 1:250-1:1000 Amorim M Martins B Caramelo F et al. Front Med-Lausanne 2022 May PMID: 35692536 Matsui T Sakamaki Y Nakashima S et al. Cell Rep 2022 May PMID: 35649370 Martin |
Storage Instruction: | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Gene Symbol: | LAMP3 |
Gene ID: | 27074 |
Uniprot ID: | LAMP3_HUMAN |
Immunogen Region: | 120aa to 175aa |
Accession Number: | ENSG00000135404 |
Specificity: | Reacts with CD63, a 40-60 kDa glycoprotein, detected by Western blot in the following human (HeLa, HUH, Jurkat) , mouse (AtT-20, Hepa, 3T3, RAW264.7) , canine (MDCK) and monkey (COS-7) whole cell lysates. |
Immunogen: | Purified recombinant peptide derived from within residues 120 aa to 175 aa of human CD63 produced in E. coli. |
Immunogen Sequence: | MENYPKNNHTASILDRMQAD FKCCGAANYTDWEKIPSMSK NRVPDSCCI |
Tissue Specificity | Detected in tonsil interdigitating dendritic cells, in spleen, lymph node, Peyer's patches in the small instestine, in thymus medulla and in B-cells (at protein level). Expressed in lymphoid organs and dendritic cells. Expressed in lung. Up-regulated in carcinomas of the esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid and parotid tissues. |
Function | Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. |
Protein Name | Lysosome-Associated Membrane Glycoprotein 3 Lamp-3 Lysosomal-Associated Membrane Protein 3 Dc-Lysosome-Associated Membrane Glycoprotein Dc Lamp Protein Tsc403 Cd Antigen Cd208 |
Cellular Localisation | Cell Surface Lysosome Membrane Single-Pass Type I Membrane Protein Cytoplasmic Vesicle Membrane Early Endosome Membrane During Dendritic Cell Maturation Detected On Cytoplasmic Vesicles (The Mhc Ii Compartment) That Contain Mhc Ii Proteins Lamp1 Lamp2 And Lamp3 Detected On Lysosomes In Mature Dendritic Cells |
Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 3 antibody Anti-Lamp-3 antibody Anti-Lysosomal-Associated Membrane Protein 3 antibody Anti-Dc-Lysosome-Associated Membrane Glycoprotein antibody Anti-Dc Lamp antibody Anti-Protein Tsc403 antibody Anti-Cd Antigen Cd208 antibody Anti-LAMP3 antibody Anti-DCLAMP antibody Anti-TSC403 antibody |
Information sourced from Uniprot.org