Anti-CD55 antibody [PTF0063] (STJA0040320)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal anti-Complement Decay-Accelerating Factor for use in FC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PTF0063 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IF 1:200-1:1000FC:1 ยตg per million cells in 100 ยตl volume. For optimal results, the reagent should be titrated according to each specific application |
| Formulation | PBS, pH 7.4 |
| Storage Instruction | Store at 4ยฐC short term. For long term storage, store at-20ยฐC, avoiding freeze/thaw cycles. |
Target Information
| Gene Symbol | CD55 |
| Gene ID | 1604 |
| Uniprot ID | DAF_HUMAN |
| Specificity | Endogenous |
Additional Info
| Post Translational Modifications | The Ser/Thr-rich domain is heavily O-glycosylated. |
| Function | This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage. (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. |
| Protein Name | Complement Decay-Accelerating FactorCd Antigen Cd55 |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-6798695Reactome: R-HSA-6807878Reactome: R-HSA-977606 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Cell MembraneLipid-AnchorGpi-AnchorIsoform 3: SecretedIsoform 4: SecretedIsoform 5: SecretedIsoform 6: Cell MembraneIsoform 7: Cell Membrane |
| Alternative Antibody Names | Anti-Complement Decay-Accelerating Factor antibodyAnti-Cd Antigen Cd55 antibodyAnti-CD55 antibodyAnti-CR antibodyAnti-DAF antibody |
Information sourced from Uniprot.org