| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Short Description : | Mouse monoclonal antibody anti-T-Cell Surface Glycoprotein Cd5 is suitable for use in Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | MCD5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | PBS with 0.2% BSA, and 0.09% Sodium Azide |
| Purification: | Protein A purification |
| Dilution Range: | Please carry out application specific titration to determine the most appropriate dilution ratio. |
| Storage Instruction: | Shipped on gel ice packs. Store at 2-8C on arrival. |
| Function | Lymphoid-specific receptor expressed by all T-cells and in a subset of B-cells known as B1a cells. Plays a role in the regulation of TCR and BCR signaling, thymocyte selection, T-cell effector differentiation and immune tolerance. Acts by interacting with several ligands expressed on B-cells such as CD5L or CD72 and thereby plays an important role in contact-mediated, T-dependent B-cell activation and in the maintenance of regulatory T and B-cell homeostasis. Functions as a negative regulator of TCR signaling during thymocyte development by associating with several signaling proteins including LCK, CD3Z chain, PI3K or CBL. Mechanistically, co-engagement of CD3 with CD5 enhances phosphorylated CBL recruitment leading to increased VAV1 phosphorylation and degradation. Modulates B-cell biology through ERK1/2 activation in a Ca(2+)-dependent pathway via the non-selective Ca(2+) channel TRPC1, leading to IL-10 production. |
| Protein Name | T-Cell Surface Glycoprotein Cd5Lymphocyte Antigen T1/Leu-1Cd Antigen Cd5 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-T-Cell Surface Glycoprotein Cd5 antibodyAnti-Lymphocyte Antigen T1/Leu-1 antibodyAnti-Cd Antigen Cd5 antibodyAnti-CD5 antibodyAnti-LEU1 antibody |
Information sourced from Uniprot.org
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