• Formalin-fixed, paraffin-embedded human Hodgkin lymphoma stained with anti-CD30 antibody using peroxidase-conjugate and DAB chromogen Note the membranous staining of Hodgkin’s cells
  • Formalin-fixed, paraffin-embedded human Hodgkin lymphoma stained with anti-CD30 antibody using peroxidase-conjugate and DAB chromogen Note the membranous staining of Hodgkin’s cells

Anti-CD30 antibody (STJ180051)

SKU:
STJ180051
Current Stock:
Host: Mouse
Applications: IHC-p
Reactivity: Human
Short Description: Mouse monoclonal primary antibody against CD30.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: Ber‐H2
Conjugation: Unconjugated
Formulation: Purified antibody diluted in Tris‐HCI buffer containing stabilizing protein and <0.1% sodium azide.
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Isotype: IgG1 Kappa
Dilution Range: 1:100‐200
Uniprot ID: TNR8_HUMAN
Gene ID: 943
Gene Symbol: TNFRSF8
Immunogen: Co cell line established from a patient with Hodgkin's disease of T‐cell lineage
Background CD30, a single chain glycoprotein, is synthesized as a 90kDa precursor which is processed in the Golgi complex into a membrane‐bound phosphorylated mature 105/120kDa glycoprotein. The CD30/Ki‐1 antigen is expressed by mononuclear Hodgkin and multinucleated Reed‐Sternberg cells in Hodgkin’s disease, by the tumor cells of a majority of anaplastic large cell lymphomas, and by a varying proportion of activated T and B cells. Ber‐H2 distinguishes large cell lymphomas derived from activated lymphoid cells from histiocytic malignancies and lymphomas derived from resting and precursor lymphoid cells or from anaplastic carcinomas. About one third of the Ki‐1 positive lymphomas lack the leukocyte common antigen (CD45).
Tissue Specificity Isoform 2: Detected in alveolar macrophages (at protein level).
Post Translational Modifications Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated.
Function Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B.
Database Links Reactome: R-HSA-5669034
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 8
Cd30l Receptor
Ki-1 Antigen
Lymphocyte Activation Antigen Cd30
Cd Antigen Cd30
Alternative Names Anti-Tumor Necrosis Factor Receptor Superfamily Member 8 antibody
Anti-Cd30l Receptor antibody
Anti-Ki-1 Antigen antibody
Anti-Lymphocyte Activation Antigen Cd30 antibody
Anti-Cd Antigen Cd30 antibody
Anti-TNFRSF8 antibody
Anti-CD30 antibody
Anti-D1S166E antibody
Positive Control Hodgkin lymphoma or anaplastic large cell lymphoma.

Information sourced from Uniprot.org

6 months standard