| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD2AP (360-639) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD2AP |
| Gene ID: |
23607 |
| Uniprot ID: |
CD2AP_HUMAN |
| Immunogen Region: |
360-639 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 360-639 of human CD2AP (NP_036252.1). |
| Immunogen Sequence: |
KYFSLKPEEKDEKSTLEQKP SKPAAPQVPPKKPTPPTKAS NLLRSSGTVYPKRPEKPVPP PPPIAKINGEVSSISSKFET EPVSKLKLDSEQLPLRPKSV DFDSLTVRTSKETDVVNFDD IASSENLLHLTANRPKMPGR RLPGRFNGGHSPTHSPEKIL KLPKEEDSANLKPSELKKDT CYSPKPSVYLSTPSSASKAN TTAFLTPLEIKAKVETDDVK KNSLDELRAQIIELLCIVE |
| Tissue Specificity | Widely expressed in fetal and adult tissues. |
| Post Translational Modifications | Phosphorylated on tyrosine residues.probably by c-Abl, Fyn and c-Src. |
| Function | Seems to act as an adapter protein between membrane proteins and the actin cytoskeleton. In collaboration with CBLC, modulates the rate of RET turnover and may act as regulatory checkpoint that limits the potency of GDNF on neuronal survival. Controls CBLC function, converting it from an inhibitor to a promoter of RET degradation. May play a role in receptor clustering and cytoskeletal polarity in the junction between T-cell and antigen-presenting cell. May anchor the podocyte slit diaphragm to the actin cytoskeleton in renal glomerolus. Also required for cytokinesis. Plays a role in epithelial cell junctions formation. |
| Protein Name | Cd2-Associated ProteinAdapter Protein CmsCas Ligand With Multiple Sh3 Domains |
| Database Links | Reactome: R-HSA-373753 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionRuffleCell JunctionColocalizes With F-Actin And Bcar1/P130cas In Membrane RufflesLocated At Podocyte Slit Diaphragm Between Podocyte Foot ProcessesDuring Late Anaphase And TelophaseConcentrates In The Vicinity Of The Midzone Microtubules And In The Midbody In Late Telophase |
| Alternative Antibody Names | Anti-Cd2-Associated Protein antibodyAnti-Adapter Protein Cms antibodyAnti-Cas Ligand With Multiple Sh3 Domains antibodyAnti-CD2AP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
