Anti-CD261/TNFRSF10A/DR4 antibody [Fs0356] {FITC} (STJA0031908)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationFITC
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal anti-CD261/TNFRSF10A/DR4 for use in FCM in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FCM |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | Fs0356 |
| Isotype | IgG2ak |
| Conjugation | FITC |
| Purification | Affinity chromatography |
| Formulation | 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
| Endotoxin | Please contact us for this information. |
Target Information
| Gene Symbol | TNFRSF10A |
| Gene ID | 8797 |
| Uniprot ID | TR10A_HUMAN |
Additional Info
| Post Translational Modifications | Palmitoylated. Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death. Palmitoylated by ZDHHC3 (Probable). |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10aDeath Receptor 4Tnf-Related Apoptosis-Inducing Ligand Receptor 1Trail Receptor 1Trail-R1Cd Antigen Cd261 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftCytoplasmCytosolPalmitoylation Is Required For Association With Membranes |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10a antibodyAnti-Death Receptor 4 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 1 antibodyAnti-Trail Receptor 1 antibodyAnti-Trail-R1 antibodyAnti-Cd Antigen Cd261 antibodyAnti-TNFRSF10A antibodyAnti-APO2 antibodyAnti-DR4 antibodyAnti-TRAILR1 antibody |
Information sourced from Uniprot.org