Anti-CD133 antibody [SM0392] (STJA0010392)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenKLH conjugated Synthetic peptide corresponding to Mouse CD133
General Information
| Short Description | Mouse monoclonal anti-CD133 for use in IHC and IF in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SM0392 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | IHC/IF (R) 1:200-1:800/1:200-1:800 |
| Formulation | PBS with 0.02% sodium azide, 100 Mu g/ml BSA and 50% glycerol. |
| Storage Instruction | Store at-20C for up to one year, and avoid repeated freeze-thaw cycles. |
Target Information
| Gene Symbol | Prom1 |
| Gene ID | 19126 |
| Uniprot ID | PROM1_MOUSE |
| Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse CD133 |
Additional Info
| Post Translational Modifications | Acetylation at Lys-226, Lys-258 and Lys-265 by NAT8 and NAT8B may control PROM1 protein expression and its function in cell apoptosis. |
| Function | May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis. Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. |
| Protein Name | Prominin-1Antigen Ac133 HomologProminin-Like Protein 1Cd Antigen Cd133 |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell ProjectionMicrovillus MembraneCiliumPhotoreceptor Outer SegmentEndoplasmic ReticulumEndoplasmic Reticulum-Golgi Intermediate CompartmentFound In Extracellular Membrane Particles In Various Body Fluids Such As Ventricular Fluid Of The Developing Brain And Urine |
| Alternative Antibody Names | Anti-Prominin-1 antibodyAnti-Antigen Ac133 Homolog antibodyAnti-Prominin-Like Protein 1 antibodyAnti-Cd Antigen Cd133 antibodyAnti-Prom1 antibodyAnti-Prom antibodyAnti-Proml1 antibody |
Information sourced from Uniprot.org