Anti-CD103 antibody (191-385 aa) (STJ11104994)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CD103 (191-385 aa) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Itgae |
| Gene ID | 16407 |
| Uniprot ID | ITAE_MOUSE |
| Immunogen Region | 191-385 aa |
| Immunogen Sequence | EDGTEIAIVLDGSGSIEPSD FQKAKNFISTMMRNFYEKCF ECNFALVQYGAVIQTEFDLQ ESRDINASLAKVQSIVQVKE VTKTASAMQHVLDNIFIPSR GSRKKALKVMVVLTDGDIFG DPLNLTTVINSPKMQGVVRF AIGVGDAFKNNNTYRELKLI ASDPKEAHTFKVTNYSALDG LLSKLQQHIVHMEGT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 191-385 of mouse CD103. (NP_032425.2). |
Additional Info
| Function | Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall. |
| Protein Name | Integrin Alpha-EIntegrin Alpha M290Cd Antigen Cd103 Cleaved Into - Integrin Alpha-E Light Chain - Integrin Alpha-E Heavy Chain |
| Database Links | Reactome: R-MMU-216083 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Integrin Alpha-E antibodyAnti-Integrin Alpha M290 antibodyAnti-Cd Antigen Cd103 Cleaved Into - Integrin Alpha-E Light Chain - Integrin Alpha-E Heavy Chain antibodyAnti-Itgae antibody |
Information sourced from Uniprot.org