Anti-CCR3 antibody (146-226) (STJ11103242)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal CCR3 (146-226) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CCR3 |
| Gene ID | 1232 |
| Uniprot ID | CCR3_HUMAN |
| Immunogen Region | 146-226 |
| Immunogen Sequence | TVTFGVITSIVTWGLAVLAA LPEFIFYETEELFEETLCSA LYPEDTVYSWRHFHTLRMTI FCLVLPLLVMAICYTGIIKT L |
| Specificity | Recombinant fusion protein containing a sequence within amino acids 146-226 of human CCR3 (NP_001828.1). |
Additional Info
| Tissue Specificity | In eosinophils as well as trace amounts in neutrophils and monocytes. |
| Function | Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. |
| Protein Name | C-C Chemokine Receptor Type 3C C Ckr3C-C Ckr-3Cc-Ckr-3Ccr-3Ccr3Ckr 3Ckr3Eosinophil Eotaxin ReceptorCd Antigen Cd193 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 3 antibodyAnti-C C Ckr3 antibodyAnti-C-C Ckr-3 antibodyAnti-Cc-Ckr-3 antibodyAnti-Ccr-3 antibodyAnti-Ccr3 antibodyAnti-Ckr 3 antibodyAnti-Ckr3 antibodyAnti-Eosinophil Eotaxin Receptor antibodyAnti-Cd Antigen Cd193 antibodyAnti-CCR3 antibodyAnti-CMKBR3 antibody |
Information sourced from Uniprot.org