| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCR3 |
| Gene ID: | 1232 |
| Uniprot ID: | CCR3_HUMAN |
| Immunogen Region: | 146-226 |
| Specificity: | Recombinant fusion protein containing a sequence within amino acids 146-226 of human CCR3 (NP_001828.1). |
| Immunogen Sequence: | TVTFGVITSIVTWGLAVLAA LPEFIFYETEELFEETLCSA LYPEDTVYSWRHFHTLRMTI FCLVLPLLVMAICYTGIIKT L |
| Tissue Specificity | In eosinophils as well as trace amounts in neutrophils and monocytes. |
| Function | Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15. Subsequently transduces a signal by increasing the intracellular calcium ions level. In addition acts as a possible functional receptor for NARS1. (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. |
| Protein Name | C-C Chemokine Receptor Type 3 C C Ckr3 C-C Ckr-3 Cc-Ckr-3 Ccr-3 Ccr3 Ckr 3 Ckr3 Eosinophil Eotaxin Receptor Cd Antigen Cd193 |
| Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-418594 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 3 antibody Anti-C C Ckr3 antibody Anti-C-C Ckr-3 antibody Anti-Cc-Ckr-3 antibody Anti-Ccr-3 antibody Anti-Ccr3 antibody Anti-Ckr 3 antibody Anti-Ckr3 antibody Anti-Eosinophil Eotaxin Receptor antibody Anti-Cd Antigen Cd193 antibody Anti-CCR3 antibody Anti-CMKBR3 antibody |
Information sourced from Uniprot.org