• Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-CCNY antibody (STJ191671)

SKU:
STJ191671

Current Stock:
Host: Rabbit
Applications: WB, ELISA
Reactivity: Human, Mouse
Short Description: Rabbit polyclonal anti-CCNY antibody is suitable for use in Western Blot and ELISA.
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Polyclonal
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Purification: CCNY antibody was affinity-purified from rabbit antiserum by affinity-chromatography using a epitope-specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Specificity: CCNY polyclonal antibody detects endogenous levels of protein.
Uniprot ID: CCNY_HUMAN
Gene ID: 219771
Gene Symbol: CCNY
Immunogen: Synthesized peptide derived from human CCNY protein.
Immunogen Region: 270-350aa
Post Translational Modifications Ubiquitinated.leading to its degradation. Heavily phosphorylated. Phosphorylation at Ser-71 and Ser-73 by CDK14 is enhanced during the G2 and M cell cycle phases, and creates a phosphodegron triggering SCF-dependent ubiquitination.
Function Positive regulatory subunit of the cyclin-dependent kinases CDK14/PFTK1 and CDK16. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by recruiting CDK14/PFTK1 to the plasma membrane and promoting phosphorylation of LRP6, leading to the activation of the Wnt signaling pathway. Recruits CDK16 to the plasma membrane. Isoform 3 might play a role in the activation of MYC-mediated transcription.
Protein Name Cyclin-Y
Cyc-Y
Cyclin Box Protein 1
Cyclin Fold Protein 1
Cyclin-X
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Isoform 3: Nucleus
Alternative Antibody Names Anti-Cyclin-Y antibody
Anti-Cyc-Y antibody
Anti-Cyclin Box Protein 1 antibody
Anti-Cyclin Fold Protein 1 antibody
Anti-Cyclin-X antibody
Anti-CCNY antibody
Anti-C10orf9 antibody
Anti-CBCP1 antibody
Anti-CFP1 antibody

Information sourced from Uniprot.org

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